Treating patients with type 2 diabetes who cannot control blood sugar levels by diet and exercise alone. Glimepiride may be used in combination with insulin.
Glimepiride is a sulfonylurea. Glimepiride lowers blood glucose (sugar) by stimulating the release of insulin from the pancreas gland. It also may help lower blood glucose by other actions on fat and muscle cells. Glimepiride does not work in type 1 (insulin-dependent) diabetes mellitus because in this condition, the pancreas gland is not capable of making or releasing insulin.
Do NOT use Glimepiride if:
you are allergic to any ingredient in Glimepiride
you have type 1 diabetes, severe second or third degree burns, increased ketone levels, severely increased acid levels in your bodily fluids (acidosis), or a history of a diabetic coma
you are pregnant and near delivery
you are using bosentan or drink alcohol
Contact your doctor or health care provider right away if any of these apply to you.
Before using Glimepiride :
Some medical conditions may interact with Glimepiride. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have increased levels of acid in your bodily fluids (acidosis), a weak stomach, liver problems, intestinal problems, a high fever, kidney problems, severe diarrhea, an infection, or thyroid problems
if you have recently suffered from major surgery or trauma, or you are debilitated or malnourished
Some MEDICINES MAY INTERACT with Glimepiride. Tell your health care provider if you are taking any other medicines, especially any of the following:
Bosentanbecause liver problems may occur and the effectiveness may be decreased
Angiotensin converting enzyme (ACE) inhibitors (eg, enalapril), beta-blockers (eg, propranolol), certain medicines that act on the liver (eg, cimetidine, fluoxetine, miconazole, and others), chloramphenicol, clofibrate, fenfluramine, gemfibrozil, monoamine oxidase (MAO) inhibitors (eg,
phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen,
celecoxib), oral anticoagulants (eg, warfarin), probenecid, salicylates
(eg, aspirin), or sulfonamides (eg, sulfamethoxazole) because the risk of
abnormally low blood sugar levels (eg, hunger, shakiness or weakness,
dizziness, headache, sweating) may be increased
Birth control pills, certain medicines that act on the liver (eg, phenytoin, rifampin, and others), diazoxide, diuretics (eg, hydrochlorothiazide), corticosteroids (eg, prednisone), estrogens (eg, estradiol), gemfibrozil, isoniazid, nicotinic acid, phenothiazines (eg, chlorpromazine), or certain
stimulants (eg, albuterol, amphetamine, pseudoephedrine) because the
effectiveness of Glimepiride may be decreased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Glimepiride may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Glimepiride :
Use Glimepiride as directed by your doctor. Check the label on the medicine for exact dosing instructions.
The usual dose is given once daily with breakfast or the first main meal of the day.
If you miss a dose of Glimepiride , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Glimepiride.
Important safety information:
Do not drink alcohol while you are using Glimepiride. It can increase the risk of developing abnormally low blood sugar. Alcohol can sometimes interact with Glimepiride and cause a serious reaction with symptoms such as facial flushing, nausea, vomiting, dizziness, or stomach pain.
Sulfonylurea antidiabetic medicines have been associated with increased risk of death from heart disease. Talk to your doctor about the possible risks and benefits of using Glimepiride and alternative treatments for your condition.
Carry an identification card at all times that says you are diabetic. Monitor your blood sugar levels regularly according to your doctor's directions. If your blood sugar level is often higher than it should be and you are taking Glimepiride according to directions, check with your doctor.
Glimepiride may cause low blood sugar (eg, increased heartbeat, headache, chills, sweating, tremor, increased hunger, changes in vision, nervousness, weakness, dizziness, drowsiness, or fainting). It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you do not have a
reliable source of glucose available, eat a quick source of sugar, such as
table sugar, honey, or candy, or drink a glass of orange juice or nondiet
soda to quickly raise your blood sugar level. Tell your doctor immediately
about the reaction. To prevent low blood sugar levels, eat meals on a regular
schedule and do not skip meals.
Use Glimepiride with caution in the ELDERLY because they may be more sensitive to its effects, especially abnormally low blood sugar levels.
Glimepiride is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Glimepiride during pregnancy. It is unknown if Glimepiride is excreted in breast milk. Do not breast-feed while taking Glimepiride.
Possible side effects of Glimepiride :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dizziness; headache; nausea; weakness.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).
What is the shelf life of the pills?
The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
Whats wrong with my brother? is he turning mental? im scared...?
Hes been changing so much so fast! he stays in his room all day, he never talks to any of us, and two days ago he told me to tell my mom to wake him up at 5:30 and i said no just call her and he said no just tell her! and i said no just call her! and he got really mad so i ran in my room and locked the door, then he kicked a HOLE in my door and i was shocked! hes never this mad and i was gonna tell my mom anyways but he got so mad! and then he went upstairs, i didnt see him at all until just 10 minutes ago, and he walked into the kitchen and i was like are you insane? you know were broke right now and now we have to buy a new door! you do realize this isnt our house?! and he was like shut the f*ck up you little bitch and hit me so hard in the back, it hurt and i can feel a bruise coming on my back and im so shocked cause he has never actually hit me he just scares me away, he didnt go to school today and he just stayed in his room for two days after he broke the door so i didnt see him at all, hes 17 turning 18, and i dont think its drugs since hes not really in the popular crew of kids, he doesnt have many friends so where would he get the drugs? he has never even had a girlfriend, hes not bad looking but hes just quiet and unpopular. im so shocked, hes so different, what could it be? some mental thing or what? i cant talk to my parents about it cause they never believe me theyre just like oh relax, hes probably just worried about school. oh and he gets really good grades so why would he risk that for drugs?
ive been crying about this, he just isnt the same old brother i used to have...
he doesnt have any good friends here, he does on iceland but we moved from there 2 years ago
How do you like this rap song I'm writing?
I'm still going to write two more verses to this. Let me know what you honestly think. Thanks
I'm going to be using this instrumental when I record:
http://www.youtube.com/watch?v=WpeXpd6qsCE
Ted was misled as a child
He watched him Mom shoot up and Dad his walk out
Without anyone to talk about how he felt he bowed his head
Wishing for a day where he could fly instead of drown
He’d cry to his Mom to please put the pipe down
She’d reply life’s too stressful and this is my way out
He witnessed fist full of pills make their way into her mouth
One day he tried to take them away but she just hit em and shouted
You little prick! How dare you throw my last fix out
She packed Teds bags n threw him out of the house
Told him a sixteen old boy can find his own joy now
But it was cold in the south of Detroit, his pain numbed from the frost
He wasn’t even employed, he became homeless and lost
He turned thief to fill voids, showing chrome when crossed
Pursuing reefer and pills avoiding the home that he lost
He’d light his blunt up and sing his moms same song
(Chorus)
Ted began to deal anything he got his hands on
Started sniffing yayo so he could remain calm
Living selling Cane stones killing Able pained domes
Feeling hateful through the rain he drained alone
A stain was grown that then changed his love for life
He took drugs every night in spite with thugs despite
The flood raising its height, He started losing his light
Inside his mind he was moving the right way
But that was just addiction taking hold of his plays
His mind became molded like clay not to stay sober
Now instead of getting paid he was just a heavy smoker
All ways ready to dust a boulder,
Thinking about his mom, **** someone must have told her by now
That he was addicted to crack, but now smack was on his mind
So he went out and bought a needle, a lethal injection
Because people told him it’d make him feel peaceful
Being needful he filled it up with heroin
His vessels started narrowin then he heard the devil echoin
(Chorus)
How do you convince your parents to let you buy an inappropriate M game (Saints Row 3)?
Back in November my parents let me sign up for the Game fly free trial for my school's Thank's Giving break. The main thing I wanted from gamefly was Saints Row 3, since I'm in to the more free roam/do what you want games. I started playing and saw it was an incredibly fun game. I love how you can soup up your car and motorcycles. I loved that part and also the jets. It was fun to role play on since they had all the shops. So I beat its story mode and saw that it had a ton of stuff that 13 year olds shouldnt be involved in. Though I also Have 3 older brothers that talk a lot about stuff like whats in the game. My dad was going to get it for me for christmas but then my mom saw what its rated for and made him return it. She tends to be more religious since we are christians and didnt even let me get dead island because it says sexual themes on the back even though thats just cause some zombies are in bikinis. They arent too concerned with cursing in games like COD or BF3. But if this tells you anything my dad bought me read dead redemption for my birthday, knowing it has ACTUAL nudity where as saints row pixelates it. Its not like I would become some drug addict just for playing the game. The only stuff i like doing is souping up cars and skydiving. I even prefer acting like a cop in it. I'm 13 by the way. Please tell me how to convince my mom to let me get it.
To Dr. No, I do respect my parent's decisions, I just want to tweak their decisions a bit. Like I respect them and all its just my mom kinda still treats me like im 5. She doesn't even like me playing games with smoking, and Lord of the Rings, bilbo and gandalf smoke (possibly even drugs) and she loves those movies. Soooo yeah, she just treats me like I'm 5.
OH! And also thanks people for the good answers, and responding so fast too. So far 3 out of the 4 answers have been helpful......Dr. No
How do you like my verse i wrote?
I'm still going to write two more verses to this. Let me know what you honestly think. Thanks
I'm going to be using this instrumental when I record:
http://www.youtube.com/watch?v=WpeXpd6qsCE
Ted was misled as a child
He watched him Mom shoot up and Dad his walk out
Without anyone to talk about how he felt he bowed his head
Wishing for a day where he could fly instead of drown
He’d cry to his Mom to please put the pipe down
She’d reply life’s too stressful and this is my way out
He witnessed fist full of pills make their way into her mouth
One day he tried to take them away but she just hit em and shouted
You little prick! How dare you throw my last fix out
She packed Teds bags n threw him out of the house
Told him a sixteen old boy can find his own joy now
But it was cold in the south of Detroit, his pain numbed from the frost
He wasn’t even employed, he became homeless and lost
He turned thief to fill voids, showing chrome when crossed
Pursuing reefer and pills avoiding the home that he lost
He’d light his blunt up and sing his moms same song
(Chorus)
Ted began to deal anything he got his hands on
Started sniffing yayo so he could remain calm
Living selling Cane stones killing Able pained domes
Feeling hateful through the rain he drained alone
A stain was grown that then changed his love for life
He took drugs every night in spite with thugs despite
The flood raising its height, He started losing his light
Inside his mind he was moving the right way
But that was just addiction taking hold of his plays
His mind became molded like clay not to stay sober
Now instead of getting paid he was just a heavy smoker
All ways ready to dust a boulder,
Thinking about his mom, **** someone must have told her by now
That he was addicted to crack, but now smack was on his mind
So he went out and bought a needle, a lethal injection
Because people told him it’d make him feel peaceful
Being needful he filled it up with heroin
His vessels started narrowin then he heard the devil echoin
(Chorus)
Thanks guys. The last two verses are going to be the most powerful ones. I've got something really great planned for this
I want to live in a different era so badly?
I'm a 14 year old girl, and I want to live in a different era so so badly.
I wish I could grow up as boy in Manhattan in about 1900 as a newsie, when school wasn't mandatory, you played stickball for fun, kids worked, and things were just simple and fun.
Now all I hear is about all the problems in politics and all the kids I know just sit on facebook and talk about what's annoying. Nobody's ever playing outside and schools so hard and I hate it.
Girls are so dramatic and their statuses are always these stupid songs about sex and drugs that don't even make sense. Everybody's the same and when they want to have fun, they just go to the mall and buy stuff and hang out in like parking lots or something. Nobody's innocent.
I feel like growing up in this difficult time, I missed my whole childhood. I played freedom and wiffle ball and stuff, but I always was worried about school and everything. People are so interested in having what's new, and then after that they want more and more and more.
I live in northeast Philadelphia, though I want to move so badly to an area right outside of center city where there's more walkability and people outside.
I'm just so bored with today. There's nothing to do. Everybody's locked inside all the time, worrying about things. Politics, drugs, pregnancies, crimes, whatever. It's really depressing.
This bothers me all the time. I hate living in the time I live in, I think about what I can do non stop, I'm literally obsessed.
People don't understand that people were happier when things were simple, they don't stop and realize that they're contributing to the fact that everybody is depressed and boring.
What can I do?
Why hasn't anyone thought to reverse Regan's Deregulation policy?
Since Regan deregulated the financial institutions, this country has turned completely upside down. It's obvious the rich are obscenely wealthy and the impoverished get kicked (literally) down at every turn. For example, Social Security received an 3.6% cost of living adjustment, not much and completely inadequate. But for those who are eligible for food stamps (I'm not), their food stamp allowance was decreased. That's just one example. Since deregulation, living in a structure (owning or renting) is not affordable. Utilities are not affordable. Transportation is not affordable. I live on $862.00 a month. That is after medicare and some sort of medical plan is taken out. Could you live on that? And believe it or not, I'm not eligible for any type of help from any government agency because I get too much to live on. I am a natural born citizen of the U.S. and have watched our country spiral downhill for 45 years. The people who do the hard work are coming out with nothing. How strong can we be when we encourage present, past and future generations to live on credit? I can't see that as a healthy way to run any country.
Listen, I'm dirt poor (since I am disabled), and, believe me, there is no hope.
Society believes that drugs, Algol and the like are a serious problem. Sorry, they are only a symptom of the problem.
The problem is; we have a society that just does not work. We expect our young adults to begin their journey in huge debt, from their education. Work hard, buy a house; more debt. Continue living in debt till the day they die.
Where is the hope there?
Listen, I don't have hope anymore, but, please, try do do something for the generations coming up. Put regulation back, at least to a point that is livable for the majority, not just for the minority (of the wealthiest). I gotta say; the citizens of this country are dying out here!
